Page 18 - PowerPoint Presentation

HEMOFILIJA KAO JEDNA OD BOLESTI KRVI

HEMOPHILIA AS ONE OF THE BLOOD DISEASES

AUTOR: Sandra Aleksic Ucenica VIII razreda Osnovne Skole ,,Sveti Sava“

Regionalni centar za Talente Beograd 2 Mentor:Diplomirani molekularni biolog i fiziolog Arian Morina

REZIME:

Koje su bolesti krvi? Sta je hemofilija? Naslednost hemofilije? Simptomi hemofilije? Tretman hemofilije? Predostrostroznost?

Bolesti krvi i krvotvornih organa su:poremecaji eritrocitne loze,poremecaji leukocitne loze,maligne bolesti krvi,poremecaji
hemostaze i bolesti slezine.Hemofilija je nasledno oboljenje iz grupe poremedaja u procesu zgrušavanja krvi koje se javlja
uglavnom kod muškaraca jer se nasleđuje recesivno vezano za X hromozom. Hemofiličari ne krvare intenzivnije od zdravih
osoba, ali mogu krvariti mnogo duže vreme. Unutrašnje krvarenje može izazvati teška oštedenja pa čak se završiti i fatalno
(krvarenje u mozak).

Hemofilija je sklonost krvarenju, vrsta hemoragične dijateze koja se najčešde recesivno nasleđuje. Od klasične hemofilije
oboljevaju gotovo isključivo muškarci, dok žene prenose bolest na svoje sinove. Samo u izuzetnim slučajevima i žene mogu
oboleti ukoliko je otac hemofiličar, a majka konduktor.

Kako se hemofilija prenosi sa generacije na generaciju?

Geni odgovorni za proizvodnju faktora VIII i IX, koji su mutirani geni kod hemofilije, smešteni su u X hromozomu. Ovo
hemofiliju čini genetskim poremedajem povezanim sa polom osobe. Zbog činjenice da nosioci imaju jedan normalan X
hromozom koji proizvodi određenu količinu faktora VIII ili IX, oni su zaštideni od najtežeg oblika Hemofilije, pri kome je nivo
faktora zgrušavanja, u krvi, manji od 1%.Ipak, varijacije nivoa faktora zgrušavanja kod nosioca hemofilije vrlo su široke.

SUMMARY:

What are the diseases of the blood? What is hemophilia? Heritability of hemophilia? The symptoms of hemophilia?

Treatment of hemophilia? Precautions?

Diseases of blood and blood-forming organs are: erythrocyte lineage disorders, disorders of leukocyte lineage, malignant blood
diseases, disorders of hemostasis and slezine.Hemofilija disease is an inherited disorder of the group of disorders in blood
clotting process, which occurs mainly in men as related to inherited recessive X chromosome. Hemophiliacs do not bleed more
intensely than healthy people, but they can bleed a lot more time. Internal bleeding can cause severe damage and even
complete and fatal (bleeding in brain).

Hemophilia is a bleeding tendency, types of hemorrhagic diathesis, which are usually recessive inheritance. From classic
hemophilia affects almost exclusively men, while women spread the disease to their sons. Only in exceptional cases, women can
become ill if a Hemophiliac father and mother, conductor.

How Hemophilia is passed from generation to generation?

genes responsible for producing factor VIII and IX, which genes are mutated in hemophilia, are placed in the X chromosome.
This makes hemophilia genetic disorder associated with a person's gender. Due to the fact that carriers have one normal X
chromosome that produces a certain amount of factor VIII or IX, they are protected from the worst forms of hemophilia, in
which the level of clotting factor in blood, less than 1%. However, variations in levels of clotting factor in Hemophilia carrier very
broad