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ODREĐIVANJE KONCENTRACIJE ACETIL SALICILNE KISELINE

U RAZLIĈITIM VRSTAMA ASPIRINA

Autor: Nikola Jovanovid III-1, Mentor: Vesna Novovid, profesor hemije

REZIME

Cilj našeg istraživačkog rada je odreĎivanje koncentracije acestilsalicilne kiseline u
različitim vrstama aspirina, različitih proizvoĎača i poreĎenje sa vrednostima koje se nalaze na
deklaraciji. Analizirano je šest vrsta aspirina(aspirin-Bayer, andol-Pliva, midol-Hemofarm,
acetisal-Galenika, cardiopirin-PharmaSwiss, anbol-Galenika). Određivanje koncentracije je
vršeno staklenom elektrodom. Acetilsalicilna kiselina nalazi se u lekovima koji se često
koriste protiv blažih bolova, kao antipiretik (protiv groznice), i protiv zapaljenja. U malim
dozama deluje kao antikoagulans (sprečava zgrušavanje krvi), pa se koristi u sekundarnoj
prevenciji infarkta miokarda.

Rezultati koji su dobijeni pokazuju da najpribližniju koncentraciju acetil-salicilne kiseline
prema podatku sa deklaracije ima cardiopirin, proizvoĎača PharmaSwiss. Dok se najveće
odstupanje javlja kod uzorka tablete midola, proizvoĎača Hemofarm. Kod uzoraka andola,
proizvoĎača Pliva, i anbola, proizvoĎača Galenika, nismo mogli odrediti koncentraciju
acetilsalicilne kiseline, jer su puferisani.

Ključne reči: acetilsalicilna kiselina, staklena elektroda.

SUMMARY

The aim of our research is to determine the concentration of acetyl-salicylic acid in
different types of aspirin, prodused by various manufacturers and comperation with the values
specified in the product label. Six types of aspirin were analyzed (Aspirin-Bayer, Andol-Pliva,
Midol-Hemofarm, Acetisal-Galenika, Cardiopirin-PharmaSwiss, Anbol-Galenika). Determination
of concentration was performed with glass elektrode. Acetyl-salicylic acid is
found in medications that are often used to treat mild pain, as an antipyretic(againstfever)
and anti-inflammatory. In small doses acts as an anticoagulant (prevents blood clotting), and is
used in secondary prevention of myocardial infarction.

Accordin to the results, concentracion of acetyl-salicylic acid is the most similar to the
concentration given on the product label in Cardiopirin, Pharma Swiss, while the largest
deviation is with Midol pills produced by Hemofarm. In Andol produced by Pliva and Anbol
produced by Galenika the concentration of acetyl-salicylic acid couldn’t be determened because
they are buffered.

Key words: acetyl-salicylic acid, aspirin, a glass electrode.

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